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Studies have found that DSIP can be classified as peptide neuromodulator

Comprehensive Skin Improvements The mechanisms produce: Increased Skin Thickness Both epidermis and dermis show measurable thickening, reversing age-related thinning Improved Hydration Enhanced glycosaminoglycan production creates better moisture retention Significant Smoothing Collagen synthesis stimulation reduces wrinkle depth and surface irregularities Increased Elasticity Elastin production enhancement restores youthful bounce and firmness Improved Contrast (Evenness) Reduced hyperpigmentation and more uniform skin tone Enhanced Collagen I Production The primary structural collagen increases substantially Tightened Loose Skin Matrix remodeling restores structural support Barrier Protein Repair Protective skin barrier proteins receive restoration Photodamage Reduction Mottled hyperpigmentation shows correction Photoaging Protection Photoaging protection includes keratinocyte protection from lethal UV-B radiation and blocking UV-induced erythema without increasing UV sensitivity

Further, the authors would like to acknowledge support of this work by 2019 SU 0128 and 2021 SD 0018 grants from the Thringer Aufbaubank (Germany)

Gastroenterology 136 , 799805 (2009)

Gut symptoms may involve motility, inflammation, infection, immune reactions, microbiome changes, or medication effects